Wednesday, November 19, 2008

Breast Cancer Prevention Differences In Postmenopausal Women Following Calorie Restriction And Exercise

“Scientists at the University of Texas at Austin have identified pathways by which a reduced-calorie diet and exercise can modify a postmenopausal woman's risk of breast cancer. The results, presented at the American Association for Cancer Research's Seventh Annual International Conference on Frontiers in Cancer Prevention Research, suggest that both caloric restriction and exercise affect pathways leading to mTOR, a molecule involved in integrating energy balance with cell growth. Dysregulation of the mTOR pathway is a contributing factor to various human diseases, including cancers. Diet and exercise reach mTOR through different means, with calorie restriction affecting more upstream pathways, which could explain why caloric restriction is more efficient in delaying tumor growth than exercise in animal models. ‘One of the few breast cancer modifiable risk factors is obesity,’ said lead author Leticia M. Nogueira, Ph.D., a research graduate assistant at the University of Texas. ‘Our study may provide a good scientific basis for medical recommendations. If you're obese, and at high risk for breast cancer, diet and exercise could help prevent tumor growth.’”

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