“UC Irvine researchers have found a molecular link between circadian rhythms - our own body clock - and metabolism. The discovery reveals new possibilities for the treatment of diabetes, obesity and other related diseases. Paolo Sassone-Corsi, Distinguished Professor and Chair of Pharmacology, and his colleagues have identified that an essential protein called CLOCK that regulates the body's circadian rhythms, works in balance with another protein called SIRT1 that modulates how much energy a cell uses. The findings also suggest that proper sleep and diet could help maintain or rebuild the CLOCK-SIRT1 equilibrium and may help explain why lack of proper rest or disruption in our normal sleep patterns is known to increase hunger, which can lead to obesity and related illnesses and can accelerate the aging process. The specific interaction between CLOCK and SIRT1 also could lead to the development of drugs aimed at facilitating healthy metabolism, thereby helping to solve major social and medical problems such as diabetes and obesity.”
http://www.medicalnewstoday.com/articles/116164.php
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